Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer

Accelerated glucose metabolism is a common feature of cancer cells. Hexokinases catalyze the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high level in cancer cells, but only in a limited number of normal adult tissues. Using Hk2 conditional knockout mice, we showed...

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Detaylı Bibliyografya
Asıl Yazarlar: Patra, Krushna C., Wang, Qi, Bhaskar, Prashanth T., Miller, Luke, Wang, Zebin, Wheaton, Will, Chandel, Navdeep, Laakso, Markku, Muller, William J., Allen, Eric L., Jha, Abhishek K., Smolen, Gromoslaw A., Clasquin, Michelle F., Robey, Brooks, Hay, Nissim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753022/
https://ncbi.nlm.nih.gov/pubmed/23911236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.06.014
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