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Proteomics Guided Discovery of Flavopeptins: Anti-Proliferative Aldehydes Synthesized by a Reductase Domain-Containing Nonribosomal Peptide Synthetase

Due to the importance of proteases in regulating cellular processes, the development of protease inhibitors has garnered great attention. Peptide-based aldehydes are a class of compounds that exhibit inhibitory activities against various proteases and proteasomes in the context of anti-proliferative...

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Autors principals: Chen, Yunqiu, McClure, Ryan A., Zheng, Yupeng, Thomson, Regan J., Kelleher, Neil L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752840/
https://ncbi.nlm.nih.gov/pubmed/23763305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4031193
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