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Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives in vivo
Many lead compounds in the search for new drugs derive from peptides and polyketides whose similar biosynthetic enzymes have been difficult to engineer for production of new derivatives. Problems with generating multiple analogs in a single experiment along with lack of high-throughput methods for s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102229/ https://ncbi.nlm.nih.gov/pubmed/21609841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.03.008 |
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