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Akt determines cell fate through the negative regulation of the PERK-eIF2α phosphorylation pathway
Metazoans respond to various forms of environmental stress by inducing the phosphorylation of the α subunit of the translation initiation factor eIF2 at serine 51 (eIF2αP), a modification that leads to a global inhibition of mRNA translation. Herein, we demonstrate that eIF2αP is induced by pharmaco...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3752779/ https://ncbi.nlm.nih.gov/pubmed/21954288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001630 |
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