The Unfolded Protein Response and Chemical Chaperones Reduce Protein Misfolding and Colitis in Mice

BACKGROUND & AIMS: Endoplasmic reticulum (ER) stress has been associated with development of inflammatory bowel disease. We examined the effects of ER stress–induced chaperone response and the orally active chemical chaperones tauroursodeoxycholate (TUDCA) and 4-phenylbutyrate (PBA), which facil...

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Bibliografiske detaljer
Main Authors: CAO, STEWART SIYAN, ZIMMERMANN, ELLEN M., CHUANG, BRANDY–MENGCHIEH, SONG, BENBO, NWOKOYE, ANOSIKE, WILKINSON, J. ERBY, EATON, KATHRYN A., KAUFMAN, RANDAL J.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751190/
https://ncbi.nlm.nih.gov/pubmed/23336977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.01.023
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