Water-Soluble MMP-9 Inhibitor Prodrug Generates Active Metabolites That Cross the Blood–Brain Barrier

[Image: see text] MMP-9 plays a detrimental role in the pathology of several neurological diseases and, thus, represents an important target for intervention. The water-soluble prodrug ND-478 is hydrolyzed to the active MMP-9 inhibitor ND-322, which in turn is N-acetylated to the even more potent me...

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Autors principals: Song, Wei, Peng, Zhihong, Gooyit, Major, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Lee, Mijoon, Ikejiri, Masajiro, Cui, Jiankun, Gu, Zezong, Chang, Mayland
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750675/
https://ncbi.nlm.nih.gov/pubmed/23687970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400077d
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