Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile

Por Gooyit, Major, Janda, Kim D.
Publicado no Sci Rep (2016)

Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

Por Gooyit, Major, Tricoche, Nancy, Lustigman, Sara, Janda, Kim D.
Publicado em 2014

Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting

Por Gooyit, Major, Tricoche, Nancy, Javor, Sacha, Lustigman, Sara, Janda, Kim D.
Publicado no ACS Med Chem Lett (2015)

The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination

Por Marusak, Charles, Bayles, Ian, Ma, Jun, Gooyit, Major, Gao, Ming, Chang, Mayland, Bedogni, Barbara
Publicado no Pharmacol Res (2016)

Selective Gelatinase Inhibitor Neuroprotective Agents Cross the Blood-Brain Barrier

Por Gooyit, Major, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Mobashery, Shahriar, Chang, Mayland
Publicado em 2012

Selective Water-Soluble Gelatinase Inhibitor Prodrugs

Por Gooyit, Major, Lee, Mijoon, Schroeder, Valerie A., Ikejiri, Masahiro, Suckow, Mark A., Mobashery, Shahriar, Chang, Mayland
Publicado em 2011

Acceleration of diabetic wound healing using a novel protease–anti-protease combination therapy

Por Gao, Ming, Nguyen, Trung T., Suckow, Mark A., Wolter, William R., Gooyit, Major, Mobashery, Shahriar, Chang, Mayland
Publicado no Proc Natl Acad Sci U S A (2015)

Synthesis, Kinetic Characterization and Metabolism of Diastereomeric 2-(1-(4-Phenoxyphenylsulfonyl)ethyl)thiiranes as Potent Gelatinase and MT1-MMP Inhibitors

Por Gooyit, Major, Lee, Mijoon, Hesek, Dusan, Boggess, Bill, Oliver, Allen G., Fridman, Rafael, Mobashery, Shahriar, Chang, Mayland
Publicado em 2009

An Unprecedented Glycation Reactivity of a Quorum-Sensing Signaling Molecule

Por Tsuchikama, Kyoji, Gooyit, Major, Harris, Tyler L., Zhu, Jie, Globisch, Daniel, Kaufmann, Gunnar F., Janda, Kim D.
Publicado no Angew Chem Int Ed Engl (2016)

O-Phenyl Carbamate and Phenyl Urea Thiiranes as Selective Matrix Metalloproteinase-2 Inhibitors that Cross the Blood-Brain Barrier

Por Gooyit, Major, Song, Wei, Mahasenan, Kiran V., Lichtenwalter, Katerina, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Mobashery, Shahriar, Chang, Mayland
Publicado em 2013

Water-Soluble MMP-9 Inhibitor Prodrug Generates Active Metabolites That Cross the Blood–Brain Barrier

Por Song, Wei, Peng, Zhihong, Gooyit, Major, Suckow, Mark A., Schroeder, Valerie A., Wolter, William R., Lee, Mijoon, Ikejiri, Masajiro, Cui, Jiankun, Gu, Zezong, Chang, Mayland
Publicado em 2013

A Chemical Biological Strategy to Facilitate Diabetic Wound Healing

Por Gooyit, Major, Peng, Zhihong, Wolter, William R., Ping, Hualiang, Ding, Derong, Hesek, Dusan, Lee, Mijoon, Boggess, Bill, Champion, Matthew M., Suckow, Mark A., Mobashery, Shahriar, Chang, Mayland
Publicado em 2013

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse

Por Semple, Bridgette D., Noble-Haeusslein, Linda J., Gooyit, Major, Tercovich, Kayleen G., Peng, Zhihong, Nguyen, Trung T., Schroeder, Valerie A., Suckow, Mark A., Chang, Mayland, Raber, Jacob, Trivedi, Alpa
Publicado no PLoS One (2015)

Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury

Por Hadass, Orr, Tomlinson, Brittany N., Gooyit, Major, Chen, Shanyan, Purdy, Justin J., Walker, Jennifer M., Zhang, Chunyang, Giritharan, Andrew B., Purnell, Whitley, Robinson, Christopher R., Shin, Dmitriy, Schroeder, Valerie A., Suckow, Mark A., Simonyi, Agnes, Y. Sun, Grace, Mobashery, Shahriar, Cui, Jiankun, Chang, Mayland, Gu, Zezong
Publicado em 2013