Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

SB-3CT is a potent and selective inhibitor of matrix metalloproteinase (MMP)-2 and -9, which has shown efficacy in an animal model of severe traumatic brain injury (TBI). However, SB-3CT is poorly water-soluble and is metabolized primarily to p-hydroxy SB-3CT (2), a more potent inhibitor than SB-3CT...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Lee, Mijoon, Chen, Zhenzhou, Tomlinson, Brittany N., Gooyit, Major, Hesek, Dusan, Juárez, María Raquel, Nizam, Rasheeq, Boggess, Bill, Lastochkin, Elena, Schroeder, Valerie A., Wolter, William R., Suckow, Mark A., Cui, Jiancun, Mobashery, Shahriar, Gu, Zezong, Chang, Mayland
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800744/
https://ncbi.nlm.nih.gov/pubmed/26241578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00140
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