Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury

SB-3CT is a potent and selective inhibitor of matrix metalloproteinase (MMP)-2 and -9, which has shown efficacy in an animal model of severe traumatic brain injury (TBI). However, SB-3CT is poorly water-soluble and is metabolized primarily to p-hydroxy SB-3CT (2), a more potent inhibitor than SB-3CT...

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Publicat a:ACS Chem Neurosci
Autors principals: Lee, Mijoon, Chen, Zhenzhou, Tomlinson, Brittany N., Gooyit, Major, Hesek, Dusan, Juárez, María Raquel, Nizam, Rasheeq, Boggess, Bill, Lastochkin, Elena, Schroeder, Valerie A., Wolter, William R., Suckow, Mark A., Cui, Jiancun, Mobashery, Shahriar, Gu, Zezong, Chang, Mayland
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800744/
https://ncbi.nlm.nih.gov/pubmed/26241578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00140
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