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Limitations of Knockout Mice and Other Tools in Assessment of the Involvement of Matrix Metalloproteinases in Wound Healing and the Means to Overcome Them

[Image: see text] Matrix metalloproteinases (MMPs) play important roles in wound healing, but attribution of their functions in repair of wounds has been challenging. Commonly used tools such as MMP-knockout mice and zymography often confound analysis, which is complicated further as these enzymes e...

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Veröffentlicht in:ACS Pharmacol Transl Sci
Hauptverfasser: Nguyen, Trung T., Wolter, William R., Anderson, Bowen, Schroeder, Valerie A., Gao, Ming, Gooyit, Major, Suckow, Mark A., Chang, Mayland
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7296540/
https://ncbi.nlm.nih.gov/pubmed/32566914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00109
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