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PROTON BRIDGING IN THE INTERACTIONS OF THROMBIN WITH HIRUDIN AND ITS MIMICS()
Thrombin is the pivotal serine protease enzyme in the blood cascade system and thus a target of drug design for control of its activity. The most efficient non-physiologic inhibitor of thrombin is hirudin, a naturally occurring small protein. Hirudin and its synthetic mimics employ a range of hydrog...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3750058/ https://ncbi.nlm.nih.gov/pubmed/23517305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301625a |
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