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Deuterium Solvent Isotope Effect and Proton Inventory Studies of Factor Xa-catalyzed Reactions

Kinetic solvent isotope effects (KSIE) for the Factor Xa (FXa)-catalyzed activation of prothrombin in the presence and absence of Factor Va (FVa) and 5.0 ×10(−5) M phospholipid vesicles, are slightly inverse, 0.82−0.93, when substrate concentrations are at 0.2 K(m). This is consistent with rate-dete...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Daoning, Kovach, Ildiko M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2006
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535812/
https://ncbi.nlm.nih.gov/pubmed/17115712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061218m
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