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PROTON BRIDGING IN THE INTERACTIONS OF THROMBIN WITH SMALL INHIBITORS
Thrombin is the pivotal serine protease enzyme in the blood cascade system. Phe-Pro-Arg-chloromethylketone (PPACK), phosphate and phosphonate ester inhibitors form a covalent bond with the active-site Ser of thrombin. PPACK, a mechanism-based inhibitor, and the phosphate/phosphonate esters form addu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2800789/ https://ncbi.nlm.nih.gov/pubmed/19530705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900098s |
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