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Humanized mice for immune system investigation: progress, promise and challenges

PREFACE: Significant advances in our understanding of the in vivo functions of human cells, tissues and immune systems have resulted from the development of mouse strains that are based on severely immunodeficient mice expressing mutations in the interleukin-2 (IL-2) receptor common γ-chain locus. T...

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Détails bibliographiques
Auteurs principaux: Shultz, Leonard D., Brehm, Michael A., Garcia, J. Victor, Greiner, Dale L.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749872/
https://ncbi.nlm.nih.gov/pubmed/23059428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3311
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