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Humanized mice for immune system investigation: progress, promise and challenges

PREFACE: Significant advances in our understanding of the in vivo functions of human cells, tissues and immune systems have resulted from the development of mouse strains that are based on severely immunodeficient mice expressing mutations in the interleukin-2 (IL-2) receptor common γ-chain locus. T...

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Detalhes bibliográficos
Main Authors: Shultz, Leonard D., Brehm, Michael A., Garcia, J. Victor, Greiner, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749872/
https://ncbi.nlm.nih.gov/pubmed/23059428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri3311
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