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Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells

Immunodeficient mice are being used as recipients of human hematopoietic stem cells (HSC) for in vivo analyses of human immune system development and function. The development of several stocks of immunodeficient Prkdc(scid) (scid), or recombination activating 1 or 2 gene (Rag1 or Rag2) knockout mic...

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Détails bibliographiques
Publié dans:Methods Mol Biol
Auteurs principaux: Hasgur, Suheyla, Aryee, Ken Edwin, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268072/
https://ncbi.nlm.nih.gov/pubmed/27150084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-3661-8_4
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