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Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells

Immunodeficient mice are being used as recipients of human hematopoietic stem cells (HSC) for in vivo analyses of human immune system development and function. The development of several stocks of immunodeficient Prkdc(scid) (scid), or recombination activating 1 or 2 gene (Rag1 or Rag2) knockout mic...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Hasgur, Suheyla, Aryee, Ken Edwin, Shultz, Leonard D., Greiner, Dale L., Brehm, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268072/
https://ncbi.nlm.nih.gov/pubmed/27150084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-3661-8_4
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