The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

Autophagy may control the de novo refractoriness of HER2 gene-amplified breast carcinomas to the monoclonal antibody trastuzumab (Herceptin). Tumor cells originally obtained from a patient who rapidly progressed on trastuzumab ab initio display increased cellular levels of the LC3-II protein—a findi...

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Hlavní autoři: Cufí, Sílvia, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cuyàs, Elisabet, López-Bonet, Eugeni, Martin-Castillo, Begoña, Joven, Jorge, Menendez, Javier A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749547/
https://ncbi.nlm.nih.gov/pubmed/23965851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02469
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