Transforming Growth Factor-β–Induced Cross Talk Between p53 and a MicroRNA in the Pathogenesis of Diabetic Nephropathy

Elevated p53 expression is associated with several kidney diseases including diabetic nephropathy (DN). However, the mechanisms are unclear. We report that expression levels of transforming growth factor-β1 (TGF-β), p53, and microRNA-192 (miR-192) are increased in the renal cortex of diabetic mice,...

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Autors principals: Deshpande, Supriya D., Putta, Sumanth, Wang, Mei, Lai, Jennifer Y., Bitzer, Markus, Nelson, Robert G., Lanting, Linda L., Kato, Mitsuo, Natarajan, Rama
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2013
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749352/
https://ncbi.nlm.nih.gov/pubmed/23649518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0305
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