Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy

TGF-β1 upregulates microRNA-192 (miR-192) in cultured glomerular mesangial cells and in glomeruli from diabetic mice. miR-192 not only increases collagen expression by targeting the E-box repressors Zeb1/2 but also modulates other renal miRNAs, suggesting that it may be a therapeutic target for diab...

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Bibliographic Details
Main Authors: Putta, Sumanth, Lanting, Linda, Sun, Guangdong, Lawson, Gregory, Kato, Mitsuo, Natarajan, Rama
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2012
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294315/
https://ncbi.nlm.nih.gov/pubmed/22223877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011050485
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