Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is unclear. We show for the first time that SOCS5 can int...

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Main Authors: Linossi, Edmond M., Chandrashekaran, Indu R., Kolesnik, Tatiana B., Murphy, James M., Webb, Andrew I., Willson, Tracy A., Kedzierski, Lukasz, Bullock, Alex N., Babon, Jeffrey J., Norton, Raymond S., Nicola, Nicos A., Nicholson, Sandra E.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749136/
https://ncbi.nlm.nih.gov/pubmed/23990909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070536
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