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Deletion of the SOCS box of Suppressor of Cytokine Signaling-3 (SOCS3) in Embryonic Stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation
The mechanism by which Suppressor of Cytokine Signaling-3 (SOCS3) negatively regulates cytokine signaling has been widely investigated using over-expression studies in cell lines and is thought to involve interactions with both the gp130 receptor and JAK1. Here, we compare the endogenous JAK/STAT si...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437335/ https://ncbi.nlm.nih.gov/pubmed/19056487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.11.002 |
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