Deletion of the SOCS box of Suppressor of Cytokine Signaling-3 (SOCS3) in Embryonic Stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

The mechanism by which Suppressor of Cytokine Signaling-3 (SOCS3) negatively regulates cytokine signaling has been widely investigated using over-expression studies in cell lines and is thought to involve interactions with both the gp130 receptor and JAK1. Here, we compare the endogenous JAK/STAT si...

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Detalhes bibliográficos
Main Authors: Boyle, Kristy, Zhang, Jian Guo, Nicholson, Sandra E., Trounson, Evelyn, Babon, Jeffery J., McManus, Edward J., Nicola, Nicos A., Robb, Lorraine
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437335/
https://ncbi.nlm.nih.gov/pubmed/19056487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.11.002
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