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Endothelial human dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling
Tetrahydrobiopterin (BH(4)) is required for NO synthesis and inhibition of superoxide release from eNOS. Clinical trials using BH(4) to treat endothelial dysfunction have produced mixed results. Poor outcomes may be explained by the rapid systemic and cellular oxidation of BH(4). One of the oxidatio...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748942/ https://ncbi.nlm.nih.gov/pubmed/23707606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.035 |
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