Endothelial human dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling

Tetrahydrobiopterin (BH(4)) is required for NO synthesis and inhibition of superoxide release from eNOS. Clinical trials using BH(4) to treat endothelial dysfunction have produced mixed results. Poor outcomes may be explained by the rapid systemic and cellular oxidation of BH(4). One of the oxidatio...

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Main Authors: Whitsett, Jennifer, Filho, Artur Rangel, Sethumadhavan, Savitha, Celinska, Joanna, Widlansky, Michael, Vásquez-Vivar, Jeannette
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748942/
https://ncbi.nlm.nih.gov/pubmed/23707606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.035
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