Endothelial human dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling

Tetrahydrobiopterin (BH(4)) is required for NO synthesis and inhibition of superoxide release from eNOS. Clinical trials using BH(4) to treat endothelial dysfunction have produced mixed results. Poor outcomes may be explained by the rapid systemic and cellular oxidation of BH(4). One of the oxidatio...

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Bibliographische Detailangaben
Hauptverfasser: Whitsett, Jennifer, Filho, Artur Rangel, Sethumadhavan, Savitha, Celinska, Joanna, Widlansky, Michael, Vásquez-Vivar, Jeannette
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748942/
https://ncbi.nlm.nih.gov/pubmed/23707606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.035
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