Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

The docking protein FRS2α has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs). We have demonstrated that targeted disruption of FRS2α gene causes severe impairment in mouse development resulting in embryonal lethality at E7.0–E7.5. Experiments with FRS2α-def...

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Bibliographic Details
Main Authors: Hadari, Y. R., Gotoh, N., Kouhara, H., Lax, I., Schlessinger, J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC37478/
https://ncbi.nlm.nih.gov/pubmed/11447289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161259898
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