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FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

Attenuation of growth factor signaling is essential for the regulation of developmental processes and tissue homeostasis in most organisms. The product of Cbl protooncogene is one such regulator, which functions as an ubiquitin ligase that ubiquitinates and promotes the degradation of a variety of c...

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Bibliografische gegevens
Hoofdauteurs: Wong, Andy, Lamothe, Betty, Lee, Arnold, Schlessinger, Joseph, Lax, Irit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC124463/
https://ncbi.nlm.nih.gov/pubmed/11997436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052138899
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