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FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

Attenuation of growth factor signaling is essential for the regulation of developmental processes and tissue homeostasis in most organisms. The product of Cbl protooncogene is one such regulator, which functions as an ubiquitin ligase that ubiquitinates and promotes the degradation of a variety of c...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wong, Andy, Lamothe, Betty, Lee, Arnold, Schlessinger, Joseph, Lax, Irit
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC124463/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11997436/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052138899
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