Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties, but less is known about how they induce cell death. Here, we show that both type I (α/β) and type II (γ) IFNs induce precipitous receptor-interacting protein (RIP)1/RIP3 kinase-mediated necrosis when the adapto...

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Bibliografske podrobnosti
Main Authors: Thapa, Roshan J., Nogusa, Shoko, Chen, Peirong, Maki, Jenny L., Lerro, Anthony, Andrake, Mark, Rall, Glenn F., Degterev, Alexei, Balachandran, Siddharth
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746924/
https://ncbi.nlm.nih.gov/pubmed/23898178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301218110
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