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Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties, but less is known about how they induce cell death. Here, we show that both type I (α/β) and type II (γ) IFNs induce precipitous receptor-interacting protein (RIP)1/RIP3 kinase-mediated necrosis when the adapto...

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書誌詳細
主要な著者: Thapa, Roshan J., Nogusa, Shoko, Chen, Peirong, Maki, Jenny L., Lerro, Anthony, Andrake, Mark, Rall, Glenn F., Degterev, Alexei, Balachandran, Siddharth
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746924/
https://ncbi.nlm.nih.gov/pubmed/23898178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301218110
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