Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties, but less is known about how they induce cell death. Here, we show that both type I (α/β) and type II (γ) IFNs induce precipitous receptor-interacting protein (RIP)1/RIP3 kinase-mediated necrosis when the adapto...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Thapa, Roshan J., Nogusa, Shoko, Chen, Peirong, Maki, Jenny L., Lerro, Anthony, Andrake, Mark, Rall, Glenn F., Degterev, Alexei, Balachandran, Siddharth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746924/
https://ncbi.nlm.nih.gov/pubmed/23898178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301218110
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