Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity

Elevated eukaryotic initiation factor 4E (eIF4E) levels frequently occur in a variety of human cancers. Overexpression of eIF4E promotes cellular transformation by selectively increasing the translation of proliferative and prosurvival mRNAs. These mRNAs possess highly structured 5′-UTRs that impede...

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Detaylı Bibliyografya
Asıl Yazarlar: Feoktistova, Kateryna, Tuvshintogs, Enkhee, Do, Angelie, Fraser, Christopher S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746923/
https://ncbi.nlm.nih.gov/pubmed/23901100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303781110
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