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Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity
Elevated eukaryotic initiation factor 4E (eIF4E) levels frequently occur in a variety of human cancers. Overexpression of eIF4E promotes cellular transformation by selectively increasing the translation of proliferative and prosurvival mRNAs. These mRNAs possess highly structured 5′-UTRs that impede...
Tallennettuna:
| Päätekijät: | , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746923/ https://ncbi.nlm.nih.gov/pubmed/23901100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303781110 |
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