Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation

Acute myeloid leukemia (AML) induces bone marrow (BM) failure in patients, predisposing them to life-threatening infections and bleeding. The mechanism by which AML mediates this complication is unknown but one widely accepted explanation is that AML depletes the BM of hematopoietic stem cells (HSCs...

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Autori principali: Miraki-Moud, Farideh, Anjos-Afonso, Fernando, Hodby, Katharine A., Griessinger, Emmanuel, Rosignoli, Guglielmo, Lillington, Debra, Jia, Li, Davies, Jeff K., Cavenagh, Jamie, Smith, Matthew, Oakervee, Heather, Agrawal, Samir, Gribben, John G., Bonnet, Dominique, Taussig, David C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746910/
https://ncbi.nlm.nih.gov/pubmed/23901108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301891110
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