Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(−) fraction

Leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) are believed to be restricted to the CD34(+) fraction. However, one of the most frequently mutated genes in AML is nucleophosmin (NPM), and this is associated with low CD34 expression. We, therefore, investigated whether NPM-mutated AM...

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Bibliographic Details
Main Authors: Taussig, David C., Vargaftig, Jacques, Miraki-Moud, Farideh, Griessinger, Emmanuel, Sharrock, Kirsty, Luke, Tina, Lillington, Debra, Oakervee, Heather, Cavenagh, Jamie, Agrawal, Samir G., Lister, T. Andrew, Gribben, John G., Bonnet, Dominique
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837317/
https://ncbi.nlm.nih.gov/pubmed/20053758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206565
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