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Extinction of Hepatitis C Virus by Ribavirin in Hepatoma Cells Involves Lethal Mutagenesis

Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants. To explore lethal mutagenesis of hepatitis C virus...

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Main Authors: Ortega-Prieto, Ana M., Sheldon, Julie, Grande-Pérez, Ana, Tejero, Héctor, Gregori, Josep, Quer, Josep, Esteban, Juan I., Domingo, Esteban, Perales, Celia
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745404/
https://ncbi.nlm.nih.gov/pubmed/23976977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071039
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