Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

Disruption of fast axonal transport (FAT) is an early pathological event in Alzheimer's disease (AD). Soluble amyloid-β oligomers (AβOs), increasingly recognized as proximal neurotoxins in AD, impair organelle transport in cultured neurons and transgenic mouse models. AβOs also stimulate hyperp...

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Detalhes bibliográficos
Main Authors: Ramser, Elisa M., Gan, Kathlyn J., Decker, Helena, Fan, Emily Y., Suzuki, Matthew M., Ferreira, Sergio T., Silverman, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744947/
https://ncbi.nlm.nih.gov/pubmed/23783030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-12-0858
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