Amyloid-β Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3β in Primary Cultured Hippocampal Neurons

Disruption of axonal transport is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD). Even though defective transport is considered an early pathologic event, the mechanisms by which neurodegenerative insults impact transport are poorly understood. We show that...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Decker, Helena, Lo, Karen Y., Unger, Sandra M., Ferreira, Sergio T., Silverman, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632489/
https://ncbi.nlm.nih.gov/pubmed/20610750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1074-10.2010
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