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Loss of the Anorexic Response to Systemic 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside Administration Despite Reducing Hypothalamic AMP-Activated Protein Kinase Phosphorylation in Insulin-Deficient Rats

This study tested whether chronic systemic administration of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) could attenuate hyperphagia, reduce lean and fat mass losses, and improve whole-body energy homeostasis in insulin-deficient rats. Male Wistar rats were first rendered diabetic th...

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Detalhes bibliográficos
Main Authors: Vitzel, Kaio F., Bikopoulos, George, Hung, Steven, Curi, Rui, Ceddia, Rolando B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743807/
https://ncbi.nlm.nih.gov/pubmed/23967267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071944
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