Chronic Treatment with the AMP-Kinase Activator AICAR Increases Glycogen Storage and Fatty Acid Oxidation in Skeletal Muscles but Does Not Reduce Hyperglucagonemia and Hyperglycemia in Insulin Deficient Rats

This study tested whether the glycogen-accumulating effect of chronic in vivo pharmacological 5′AMP-activated protein kinase (AMPK) activation could improve glycemic control under conditions of insulin deficiency. Male Wistar rats were rendered diabetic through the administration of streptozotocin (...

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Detalhes bibliográficos
Main Authors: Vitzel, Kaio F., Bikopoulos, George, Hung, Steven, Pistor, Kathryn E., Patterson, Jessica D., Curi, Rui, Ceddia, Rolando B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631222/
https://ncbi.nlm.nih.gov/pubmed/23620811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062190
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