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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferon...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743401/ https://ncbi.nlm.nih.gov/pubmed/23951545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00785 |
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