The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

Mitochondria serve as platforms for innate immunity. The mitochondrial antiviral signalling (MAVS) protein forms aggregates that elicit robust type-I interferon induction on viral infection, but persistent MAVS signalling leads to host immunopathology; it remains unknown how these signalling aggrega...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Yoo, Young-Suk, Park, Yong-Yea, Kim, Jae-Hoon, Cho, Hyeseon, Kim, Song-Hee, Lee, Ho-Soo, Kim, Tae-Hwan, Sun Kim, You, Lee, Youngsoo, Kim, Chul-Joong, Jung, Jae U, Lee, Jong-Soo, Cho, Hyeseong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918326/
https://ncbi.nlm.nih.gov/pubmed/26246171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8910
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