MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

RNA virus infections are detected by the RIG-I family of receptors, which induce type-I interferons through the mitochondrial protein MAVS. MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferon...

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Detalhes bibliográficos
Main Authors: Liu, Siqi, Chen, Jueqi, Cai, Xin, Wu, Jiaxi, Chen, Xiang, Wu, You-Tong, Sun, Lijun, Chen, Zhijian J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743401/
https://ncbi.nlm.nih.gov/pubmed/23951545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00785
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