The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin()

The N-terminal stretch of human frataxin (hFXN) intermediate (residues 42–80) is not conserved throughout evolution and, under defined experimental conditions, behaves as a random-coil. Overexpression of hFXN56–210 in Escherichia coli yields a multimer, whereas the mature form of hFXN (hFXN81–210) i...

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Main Authors: Faraj, Santiago E., Venturutti, Leandro, Roman, Ernesto A., Marino-Buslje, Cristina B., Mignone, Astor, Tosatto, Silvio C.E., Delfino, José M., Santos, Javier
格式: Artigo
語言:Inglês
出版: Elsevier 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741918/
https://ncbi.nlm.nih.gov/pubmed/23951553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2013.07.004
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