Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity generates PAR fragments. Here we present the cr...

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Autores principales: Barkauskaite, Eva, Brassington, Amy, Tan, Edwin S., Warwicker, Jim, Dunstan, Mark S., Banos, Benito, Lafite, Pierre, Ahel, Marijan, Mitchison, Timothy J., Ahel, Ivan, Leys, David
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741636/
https://ncbi.nlm.nih.gov/pubmed/23917065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3164
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