The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

Posttranslational modification of proteins by poly(ADP-ribosyl)ation regulates many cellular pathways that are critical for genome stability, including DNA repair, chromatin structure, mitosis and apoptosis(1). Poly(ADP-ribose) (PAR) is composed of repeating ADP-ribose units linked via a unique glyc...

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Bibliografiske detaljer
Main Authors: Slade, Dea, Dunstan, Mark S., Barkauskaite, Eva, Weston, Ria, Lafite, Pierre, Dixon, Neil, Ahel, Marijan, Leys, David, Ahel, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184140/
https://ncbi.nlm.nih.gov/pubmed/21892188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10404
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