Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O(6)-methylguanine-DNA methyltransferase activity

The poly(ADP-ribose) polymerase (PARP) inhibitor ABT-888 potentiates the antitumor activity of temozolomide (TMZ). TMZ resistance results from increased O(6)-methylguanine-DNA methyltransferase (MGMT) activity and from mismatch repair (MMR) system mutations. We evaluated the relative importance of M...

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Hauptverfasser: Horton, Terzah M., Jenkins, Gaye, Pati, Debananda, Zhang, Linna, Dolan, M. Eileen, Ribes-Zamora, Albert, Bertuch, Alison A., Blaney, Susan M., Delaney, Shannon L., Hegde, Madhuri, Berg, Stacey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741063/
https://ncbi.nlm.nih.gov/pubmed/19671751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0142
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