Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O(6)-methylguanine-DNA methyltransferase activity

The poly(ADP-ribose) polymerase (PARP) inhibitor ABT-888 potentiates the antitumor activity of temozolomide (TMZ). TMZ resistance results from increased O(6)-methylguanine-DNA methyltransferase (MGMT) activity and from mismatch repair (MMR) system mutations. We evaluated the relative importance of M...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Horton, Terzah M., Jenkins, Gaye, Pati, Debananda, Zhang, Linna, Dolan, M. Eileen, Ribes-Zamora, Albert, Bertuch, Alison A., Blaney, Susan M., Delaney, Shannon L., Hegde, Madhuri, Berg, Stacey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741063/
https://ncbi.nlm.nih.gov/pubmed/19671751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0142
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi