Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

Recent advances in our understanding of the pathogenesis of type 1 diabetes have occurred in all steps of the disease. This review outlines the pathogenic mechanisms utilized by the immune system to mediate destruction of the pancreatic beta-cells. The autoimmune response against beta-cells appears...

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Main Authors: Graham, Kate L., Sutherland, Robyn M., Mannering, Stuart I., Zhao, Yuxing, Chee, Jonathan, Krishnamurthy, Balasubramanian, Thomas, Helen E., Lew, Andrew M., Kay, Thomas W.H.
Format: Artigo
Jezik:Inglês
Izdano: SBDR - Society for Biomedical Diabetes Research 2012
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740688/
https://ncbi.nlm.nih.gov/pubmed/23804258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1900/RDS.2012.9.148
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