Dissociation of Frontotemporal Dementia–Related Deficits and Neuroinflammation in Progranulin Haploinsufficient Mice

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in social and emotional function. Heterozygous loss-of-function mutations in GRN, the progranulin gene, are a common genetic cause of the disorder, but the mechanisms by which progranulin haploinsufficiency causes ne...

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Main Authors: Filiano, Anthony J., Martens, Lauren Herl, Young, Allen H., Warmus, Brian A., Zhou, Ping, Diaz-Ramirez, Grisell, Jiao, Jian, Zhang, Zhijun, Huang, Eric J., Gao, Fen-Biao, Farese, Robert V., Roberson, Erik D.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740510/
https://ncbi.nlm.nih.gov/pubmed/23516300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6103-11.2013
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