Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generated multiple induced pluripotent stem cell (iPSC) lines from a control subject, a patient with sporadic FTD, and an FTD patient with a novel GRN mutation (PGRN S116X). In neurons and microglia differen...

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Detalhes bibliográficos
Main Authors: Almeida, Sandra, Zhang, Zhijun, Coppola, Giovanni, Mao, Wenjie, Futai, Kensuke, Karydas, Anna, Geschwind, Michael D., Tartaglia, M. Carmela, Gao, Fuying, Gianni, Davide, Sena-Esteves, Miguel, Geschwind, Daniel H., Miller, Bruce L., Farese, Robert V., Gao, Fen-Biao
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532907/
https://ncbi.nlm.nih.gov/pubmed/23063362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.09.007
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